In our study, we aimed to evaluate the efficacy of the use of a negative oral contrast agent such as gadolinium - Gd-DOTA (gadolinium-tetraazacyclododecane-tetraacetic acid-meglumine) in MRCP (Magnetic Resonance Cholangiopancreatography) for proper visualisation of the hepatobiliary tree and pancreatic duct. The fluid-filled stomach and duodenum often cause obscuration of the hepatobiliary tree and pancreatic duct. Forty-one consecutive patients, who were referred for MRCP with a clinical suspicion of pancreaticobiliary duct disease, were prospectively examined before and immediately after ingestion of a Gd-DOTA 0.5 mmol/ml solution (1 ml Gd-DOTA). The images obtained before and after the intake of a negative oral contrast agent were studied and compared. We found herein that the contrast agent Gd-DOTA (gadolinium-tetraazacyclododecane-tetraacetic acid-meglumine) constitutes an efficient negative oral contrast agent for MRCP, for it efficiently eliminates the signal of the digestive tube in MRCP images.
oral gadolinium, negative oral contrast, MRCP, pancreatobiliary system.