Background: Levobupivacaine is an S (-) enantiomer of bupivacaine having less cardiotoxic and central nervous system effects. Use of isobaric levobupivacaine in spinal anesthesia has recently been started.
Objective: To compare the anesthetic efficacy and safety of isobaric levobupivacaine versus hyperbaric bupivacaine in spinal anesthesia for lower limb orthopedic surgeries.
Materials and methods: 60 healthy patients were randomized into two groups of 30 each to receive intrathecal injection of 3ml 0.5% (15mg) of hyperbaric bupivacaine in group B and 3ml 0.5% (15mg) of isobaric levobupivacaine in group L. Both groups were compared regarding sensory- motor block characteristics, hemodynamic profile, adverse effects, supplemental analgesia and success rate.
Results: Both agents produced effective spinal anesthesia to accomplish surgery without supplementation in all 30 (100%) patients of group B and almost all (n=29, 97.6%) patients of group L. Peak sensory level was significantly higher in Group B (T6.2±1.25) than in group L (T9.33±1.65), p
intrathecal, bupivacaine, levobupivacaine, orthopedic surgery, spinal anesthesia.