OBJECTIVES: To determine the clinical presentation and outcome of acute organophosphorus
METHODS: This case series included 100 cases from various medical wards of Civil Hospital
Karachi from February 2008 to December 2008. We included all patients of organophosphorus
poisoning who showed either signs of muscarinic or nicotinic involvement. However we excluded
those patients in which organophosphorus poisoning was doubtful and who were intoxicated
with poisoning other than organophosphates.
RESULTS: Hundred patients of organophosphate poisoning were admitted among these 68%
were males and 32% were females. Modes of poisoning were suicidal in 65% of cases, accidental
in 27% and 8% were homicidal. Though the clinical presentation of acute poisoning was variable
however the most consistent feature was miosis (98%). According to W.H.O. classification
for severity of organophosphorus poisoning; 60% cases were moderate, 28% were severe and
12% were mild. The mortality rate was 20% and mostly among patients who presented with severe
symptoms and presented late.
CONCLUSION: Pesticides are the major chemical agents which pose a health threat particularly
to young people, depressed individual and farm worker so this fetal condition needs rapid diagnosis
and early treatment.
Organophosphorus; organophosphate; poisoning, suicidal, accidental, homicidal.