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J App Pharm Sci. 2016; 6(1): 023-027


Cytotoxic and Antibacterial Evaluation of Coumarins and Chromanone Acid from Calophyllum symingtonianum

Nurul Iman Aminudin, Farediah Ahmad, Muhammad Taher, Razauden Mohamed Zulkifli.

Abstract
Calophyllum symingtonianum is a rare species from the Calophyllum genus belongs to Guttiferae family. Calophyllum has been recognized as potential medicinal plant due to many bioactive phytochemicals from this plant especially coumarins and chromanone acids. In this study, the cytotoxic against MCF-7 and A-549 and antibacterial activities towards S. aureus, B. subtilis, P. aeruginosa and E. Coli of three coumarins known as inophyllum D, inophyllum H and calanone as well as chromanone acid identified as isocordato-oblongic acid isolated from this plant were evaluated. Inophyllum H exhibited the highest IC50 values against MCF-7 at 25.56 g/mL and A-549 at 26.41 g/mL. Isocordato-oblongic acid showed moderate antibacterial activity against S. aureus and B. subtilis at 125 g/mL and 62.5 g/mL, respectively. This study suggests C. symingtonianum as potential plant for cytotoxic and antibacterial phytochemicals.

Key words: Calophyllum symingtonianum, cytotoxic, antibacterial, coumarin, chromanone acid, Guttiferae



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