Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

23

J App Pharm Sci. 2016; 6(3): 101-106


Antidiarrheal property of Napoleona imperialis may be due to Procyanidins and Ellagic acid derivatives

Peter Chibueze Ihekwereme, Earnest Oghenesuvwe Erhirhie, Ikechukwu Sonne Mbagwu, Emmanuel Emeka Ilodigwe, Daniel Lotanna Ajaghaku, Festus Basden Okoye.

Abstract
Context: Diarrhea is a global epidemic. Majority of the populace in developing Countries including Nigeria depend on Napoleona imperialis as a safer, more effective and affordable alternatives for treatment of diarrhea.
Objective: This study evaluated the antidiarrheal potential of ethanol (leaf) extract and fractions of N. imperialis in Swiss albino mice.
Materials and methods: Acute toxicity test was performed to determine safe dose range before in vivo experiments. Castor-oil induced diarrhea and charcoal meal gastrointestinal motility test models were used. Antimicrobial activity on bacteria-implicated diarrhea, and HPLC analysis of the aqueous fraction (AF) were also evaluated.
Results: The result of the acute toxicity tests show that no death occurred at the test doses. Preliminary antimicrobial screening shows that the inhibitory zone diameter (IZD) of the extract has a weak antibacterial activity against sample organisms. The presence of procyanidin, 9-alpha-OH-pinoresinol, isoprunetin and ellagic acid derivatives in the aqueous fraction were highlighted by the HPLC analysis. The AF produced more significant (P

Key words: Napoleona imperialis, anti-diarrheal, antibacterial, gastrointestinal motility, castor oil, charcoal meal.



Share this Article


Advertisement
Oxidants and Antioxidants in Medical Science

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons