Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

1



CYTOTOXIC, BIOCHEMICAL AND ANTITUMOR ACTIVITY OF CAMEL URINE ON EHRLICH ASCITES CARCINOMA CELL-BEARING SWISS ALBINO MICE.

S.S. Al-Rejaie, A.M. Aleisa, S.A. Bakheet, M.M. Al-Harbi, A.M. Al-Bekairi, O.A. Al-Shabanah, Abdulhakeem Al-Majed, Abdulaziz A.Al-Yayha, S. Qureshi.

Abstract
The cytotoxic, biochemical and anti- tumor properties of Camel urine (CU) were evaluated in Ehrlich ascites carcinoma (EAC) cell-bearing mice. the anti-tumor activity of CU was evaluated on the bases of cytotoxicity and viability of EAC and their nucleic acid, protein, malondialdehyde and glutathione concentrations in addition to observations on survival of treated animals. tumors grown at the site of inoculation were evaluated for histopathological changes. The results obtained in EAC cell-bearing mice revealed the cytotoxic, biochemical and anti-tumor activity of CU to be close to that of the provency to toxic drug Cyclophosphamide (CP). Our results on the cytotoxicity and viability of some of the known constituents of CU (creatinine, adenine, and urea) revealed creatinine to be highly cytotoxic. The anti-tumor activity observed in the present study may be due to creatinine as one of the cytotoxic constituents of CU. The cytotoxic and antioxidative potentials of CU observed in the present study warrant further investigation on the active constituents of CU and their mode of action and safety before any consideration for clinical trials.

Key words: Camel urine, EAC cells, Cytotoxicity, Biochemical changes, Histopathology.



Share this Article


Advertisement
Journal of Contemporary Medical Education

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons