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A rare case of mixed connective tissue disease presenting with central nervous system glioma, vasculitis and polymyositis

Rushabh Parikh, Pushkar Ingale, Dhaval Dave, Manish Pendse, Smita Patil, Archana Bhate.

Abstract
Mixed connective tissue disease (MCTD) was first recognized by Sharp and Colleagues in 1972 among a group of patients with overlapping clinical features of systemic lupus erythematosis (SLE), scleroderma and myositis, with the presence of distinctive antibodies against, what now is known to be U1-ribonucleoprotein (RNP). We report an unusual case of a 23-year old female with MCTD characterized by the coexistence of signs, symptoms and immunological features of 3 defined autoimmune diseases SLE, systemic sclerosis (SSc), polymyositis (PM) and an unusual presence of central nervous system (CNS) Glioma.

Key words: Mixed connective tissue disease, CNS glioma, Vasculitis, Polymyositis



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