This is a descriptive study carried out in Khartoum State hospitals during the period from October 2008 to April 2011.One hundred seventy eight blood, and effusion, samples were collected from patients with accumulated effusion. Three milliliter of blood and twenty milliliter of serous effusion samples were prepared according to the Conventional Pap Smear, Enzyme-linked Immune-sorbent Assay ELISA. Malignant serous effusions were observed in 121 (62%) samples, among which 75 (62%) were in females samples and 46 (38%) were in males samples. The calculated means for all markers levels in effusion and blood samples between benign and malignant individuals showed statistical significant differences with P-value= (0.000). Except NSE blood samples level which showed no statistical significant difference with P-value= (0.665). High Pearsonís Correlation was observed between CEA effusion level and CA15-3 blood level with r=0.867.
Effusion, Malignant, CA15-3, EMA, NSE, CEA.