IJCRR. 2015; 7(22): 67-73
CLINICOPATHOLOGICAL STUDY OF ENDOMETRIUM IN PATIENTS WITH ABNORMAL UTERINE BLEEDINGHumaira Bashir, Nazia Bhat, Mehnaz Sultan Khuroo, Ruby Reshi, Mir Junaid Nazeir, Mohammad Zubair Qureshi.
Objectives: Abnormal Uterine Bleeding (AUB) is considered one of the most common and challenging problems presenting to
the gynaecologist, regardless of the age the women .The present study was done with the aim of studying the histopathological
pattern of the endometrium in women of various age groups presenting with abnormal uterine bleeding.
Methods: This was a prospective study conducted on endometrial curettings of 460 patients in the Department of Pathology,
from January 2013 to August 2014.
Results: The age of patients ranged from 18 to 70 yrs. The patients were categorized in reproductive age group (40yrs and post-menopausal group (>50yrs/clinical scenario). Maximum number of patients were in the perimenopausal
group, 220 patients (47.8%), followed by 182 patients (39.6%) in the reproductive age group. Post-menopausal patients
constituted 12.6 % ( 58) of total no of cases. Menorrhagia was the most common presenting symptom. Normal cyclic endometrium,
210 cases (45.65%), was the most common histopathological pattern seen in the reproductive and perimenopausal group,
whereas in the postmenopausal group simple hyperplasia, 16 cases (27.6%), followed by complex hyperplasia, 8 cases (13.7%)
was the commonest pattern seen. Malignancy was seen in 7 cases (1.52%)
Conclusion: Histopathological examination of endometrial curetting specimens in patients with Abnormal uterine bleeding
showed a wide spectrum of histopathological changes ranging from normal endometrium on one hand to malignancy on another
hand thus rendering endometrial curetting an important diagnostic procedure in evaluation of Abnormal uterine bleeding. Accurate
analysis of endometrial samplings is the key to effective therapy and optimal outcome
Abnormal uterine bleeding, Endometrial hyperplasia, Histopathology
American Journal of Physiology, Biochemistry and Pharmacology
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