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J App Pharm Sci. 2016; 6(10): 107-112


Synthesis, spectroscopic characterization and biological applications of Cu(II) and Ni(II) complexes with 2-butyl-4-chloro-5-formylimidazole thiosemicarbazone

A. Sreenath Reddy, L. Sivarama Krishna, H. K. Rashmi, P. Uma Maheswari Devi, Y. Sarala, A. Varada Reddy.

Abstract
Cu(II) and Ni(II) complexes of 2-butyl-4-chloro-5-formylimidazole thiosemicarbazone are synthesized and characterized by using spectroscopic techniques like elemental analysis, FT-IR, mass spectrometry, electronic and EPR spectra. The complexes are found to have characteristic electronic spectra and the geometry of the complexes are identified as an octahedron. Both the complexes are found to exhibit similar anti-microbial activity against the gram ve and gram +ve bacteria. Anti-cancer activity against the cancer cell lines (MDA-MB 231 cell lines) among the compounds studied for % of viability, the inhibition concentration 50 values were shown by Cu(II)-L complex at 80 mg/ml and by Ni(II)-L complex at 100 mg/ml.

Key words: Cu(II) and Ni(II) complexes; EPR spectra; antimicrobial activity; MDA-MB 231 cell lines



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