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Biochemical assessment of liver in sickle cell disease patients at a tertiary care hospital of north India

Pankaj Tripathi, Manju Tripathi.

Abstract
Background: Sickle cell disease (SCD) is frequently associated with liver disease. The constant state of hemolysis due to reduced red cell survival; and multiple blood transfusions will lead to hepatic sinusoidal congestion, viral hepatitis, cholestasis, and haemosiderosis, all of these may contribute to the development of liver disease. The aim of the study was to assess the biochemical liver function tests in steady state adult SCD patients in a tertiary care hospital
Methods: Fifty seven adult SCD patients in steady state and sixty hemoglobin AA controls were enrolled in the study. Liver function tests were carried out in all subjects.
Results: The serum total bilirubin, aspartate transaminase (AST) and alanine transaminase (ALT), alkaline phosphatase (ALP), direct and indirect bilirubin and total protein were significantly higher in SCD patients (P

Key words: Liver function tests, Sickle cell anaemia, Serum iron, Ferritin



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