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Retrospective evaluation of the cases with neonatal sepsis and antibiotic resistance of the causing microorganisms

Abdurrahman Avar Özdemir, Yusuf Elgörmüş.

Abstract
Objective: This study was performed to evaluate the demographical features, risk factors, responsible microorganisms, antibiotic resistance of newborns with sepsis in a neonatal intensive care unit (NICU).
Material and Method: A total of 121 patients who were diagnosed with sepsis between May 2014 and May 2015 in our NICU were evaluated retrospectively. The cases were investigated in terms of gender, birth weight, gestational age, risk factors, clinical and laboratory findings, cerebrospinal fluid (CSF) analysis and biochemistry, cultures of blood, urine and CSF, distribution of microorganisms, and antibiotic resistance.
Results: A total of 431 patients were admitted to NICU during the study period. Of these, 121 (28%) patients were diagnosed as neonatal sepsis. Early and late-onset sepsis were diagnosed in 85 (70.3%) and 36 (29.7%) cases respectively, and 24 (19.8%) cases were premature. At least one risk factor was identified in 60% of patients with sepsis. Bacterial growth was detected in 39 (32%) of total cultures. The most isolated microorganisms were S.aureus (30.2%), K.pneumoniae (25.5%) and S.epidermidis (16.2%).
Conclusions: The changing spectrum of etiology and increasing drug resistance in neonatal sepsis may pose a serious problem. Therefore, the risk factors, responsible microorganisms, and antibiotic resistance in neonatal sepsis must be determined for every NICU to start appropriate ampirical antimicrobial therapy.

Key words: Antibiotic resistance, sepsis, newborn



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