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Impact of anti-epileptic drugs on cognition: a review

Jayant Rai, Aashal Shah, Preeti P. Yadav, Mayur Chaudhari.

Epilepsy is a chronic disorder of brain caused by various factors which may vary according to the patient age. In epilepsy threshold for seizure generation get reduced. It may affect patientís living and increases morbidity. Anti-epileptic drugs are given as mono or poly-therapy for seizure control. These anti-epileptics produce side-effects which are dose and duration of the treatment dependent. One of the important side effects is impact on cognitive function of the patient. However, some anti-epileptic medications also cause improvement in the cognitive function. Newer anti-epileptics are providing better compliance and impact as compared to older ones.

This review article provides details of impact of anti-epileptic drugs on cognitive functioning.

Key words: Epilepsy, Seizure, Epileptogenesis, Partial seizures, Generalized seizures, Cognition, Anticonvulsants, Anti-epileptics

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American Journal of Physiology, Biochemistry and Pharmacology


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