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IJCRR. 2016; 8(1): 51-54


COMPARISION OF THE ADVERSE EFFECTS PROFILE OF TRAVOPROST VS BRIMONIDINE/TIMOLOL IN PATIENTS OF PRIMARY OPEN ANGLE GLAUCOMA IN CENTRAL IDIAN POPULATION OF BHOPAL

Rekha Mehani, Major V. K. Yadav, Rajnish Kumar Sankadia, Sarang Ghodki, Tanu Garg.

Abstract
Aim: To compare the adverse effects profile of Travoprost vs Brimonidine/Timolol in patients of Primary Open Angle
Glaucoma(POAG)
Methodology: In this randomized open label 12-week study, 70 patients were randomized to receive either 0.004% of Travoprost
once daily in the evening or Brimonidine/Timolol combination twice daily. Their safety was concluded by monitoring their
adverse effects during follow-up visits at 2, 4, 8, and 12 weeks.
Results: Both treatment regimens were well tolerated during the period of study. Patients in the Travoprost group had a higher
incidence of ocular irritation (30%), pigmentation of skin (33%), Thickening of eyelashes (39%) and hyperemia (36%) when compared
to the Brimonidine/Timolol group which showed only ocular irritation (21%) and foreign body sensations (28%).
Conclusions: The incidence of adverse effects were not significantly different between Travoprost and Brimonidine/Timolol
therapy. Both had favourable safety profiles. However, Travoprost had more local side effects profile when compared to Brimonidine/
Timolol.

Key words: Beta blocker, Intraocular pressure, Prostaglandin analogue, α2 agonist, Adverse effects



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