Background: obese type 2 diabetic patients have higher visceral adiposity than others, and thus more adipokines activity, which in turn affect whole body metabolism and cause multiple complications and consequences such as cardiovascular disease and insulin resistance. Purpose of the Study: To investigate the effect of Aerobic exercise on plasminogen activator inhibitor 1 (PAI 1) and visfatin levels in obese diabetic patients. Subjects and Methods: Thirty obese diabetic patients from both ganders, aged from 40 to 55 years old were enrolled in this study. They were randomly assigned to Group (A) and Group (B), 15 patients each .Group (A) received aerobic exercise in form of stationary bicycle in addition to their traditional medication , while Group( B) received their traditional medication only.. PAI 1 and Visfatin levels were evaluated before and after treatment period by using ELISA reader. Results: Improvement of PAI 1 and Visfatin were observed in the study group at the end of the study (P-value < 0.05) with no change in the control group (P-value > 0.05). On comparing the mean values of PAI 1 and Visfatin between both groups a statistical significant difference was observed (P-value < 0.05) at the end of the study in favor of the study group with 41.48% and 2.99% decrease in PAI 1 and 35.73% and 4.52% decrease in Visfatin in study and control group respectively. Conclusion: Aerobic exercise is beneficial on lowering PAI 1 and Visfatin in obese diabetic patients, and hence decreases the risk of cardiovascular disease and insulin resistance in obese diabetic patients.
Adipokines, Diabetes mellitus type 2, obesity, aerobic exercise.