Toxic Epidermal Necrolysis (TEN) is acute life-threatening mucocutaneous reactions, which are mainly induced by drugs. The annual incidence is 0.51.2 cases per million population and the mortality rate is 2030%. The genetic background associated with drug hypersensitivity is very important in the development of TEN. Antimicrobials and anticonvulsants are most commonly associated with the development of TEN. TEN is a disease which acutely starts and has prodromes such as cough lasting 1-3 days, throat ache, burning eyes, arthralgia before the disease. Intraoral erosion is a constant result. Sepsis and respiratory insufficiency were the most important complications in TEN. The main therapy are drugs used by the patient were stopped, systemic corticosteroid and supportive treatment. The aim of our study is recognized of TEN by emergency physicians.