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Original Article

J App Pharm Sci. 2016; 6(10): 045-054


Protective and therapeutic impact of taurine on some biochemical, immunological and histological parameters in diabetic rats

Doaa S. Foda, Ebtehal K. Farrag, Nadia S. Metwally, Amany S. Maghraby, Abdel Razik H. Farrag, Sayed M. Rawi.

Abstract
Background: Taurine is a non protein amino acid found in most animal tissues. It is a powerful antioxidant which shares in combating the harmful effect of the reactive oxygen species (ROS), associated to many chronic diseases as diabetes mellitus (DM) which characterized with hyperglycemia and disorders in the metabolic pathways of the body that leads to the release of ROS in the cells. Methods: The present work evaluates the biochemical and immunological role of taurine (500 mg/kg bwt) in ameliorating diabetes harm in rats and compared with the effect of the antidiabetic drug (amaryl). Six groups were established for the experiment. Group1: control rats without any supplementations. Group 2 was diabetic non treated rats. Group 3: rats received taurine for three weeks. Group 4: rats were supplemented with taurine for three weeks then injected streptozotocin (STZ) (prophylactic gp). Group 5: rats were injected with STZ then supplemented with taurine for four weeks (therapeutic gp). Group 6: rats were injected STZ then treated with amaryl drug for four weeks. Serum glucose and insulin levels in addition to liver function enzymes and lactate dehydrogenase enzyme were determined. Glutathione reductase enzyme activity and lipid peroxidation were monitored in liver tissue by measuring malondialdhyde resulting from lipid peroxidation. With respect to the immunological responses the thymocytes and splenocytes numbers were counted besides measuring serum IgG level. Histological and immunohistochemical studies were performed in pancreatic sections. Results: showed the ability of taurine in decreasing glucose level and increasing insulin with the same efficacy as amaryl drug besides affecting liver enzymes and improving the antioxidant system in cells. Taurine also restored the decrease in mean number of thymocytes and splenocytes caused by DM. Sera IgG levels from pre- and post-treatment with taurine showed non significant increase compared to the diabetic non treated group. Conclusion: post-treatment supplemention of taurine is recommended for T2DM.

Key words: Key words: Taurine –Diabetes –Insulin – Amaryl –Antioxidants-Thymocytes-Splenocytes-IgG.



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