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PAFMJ. 2016; 66(2): 240-243


COMPARISON OF FIRST MORNING VOID URINE SPECIMEN FOR ALBUMIN TO CREATININE RATIO COMPARING WITH 24-HOUR URINARY ALBUMIN EXCRETION IN DETECTING MICROALBUMINURIA IN TYPE 2 DIABETICS

Fawad Ahmad, Aamir Hussain, Omer Bin Abdul Aziz, Naveed Ahmed.

Abstract
Objectives: To determine the accuracy of first morning void urine specimen for Albumin to Creatinine Ratio (ACR) comparing with 24-hour urinary albumin excretion in detecting microalbuminuria in type 2 diabetics.
Study Design: Cross Sectional study
Place and Duration of Study: Military Hospital Rawalpindi, from Apr 2013 to Oct 2013.
Patients and Methods: One hundred & twenty patients with type 2 Diabetes Mellitus (DM) fulfilling the inclusion criteria were included in study using consecutive non-probability sampling. A standard protocol was followed for specimen collection. Urine collection was started from the next day of admission.
Results: Mean random plasma glucose level was 174.54 ± 33.06 mg/dL, mean HbA1c was 8.5 ± 1.32 %, mean urinary albumin 130.26 ± 47.25 mg/24 hour and mean ACR was 104.30 ± 51.56 mg/g. Area under ROC curve was 0.964 for microalbuminuria by ACR. Spearman’s rank-order coefficient (rs) was 0.696 for ACR and 24 hour albumin excretion.
Conclusion: ACR in first morning void urine accurately detected early microalbuminuria in type 2 diabetics.

Key words: Albumin to Creatinine Ratio, Diabetes Mellitus, Microalbuminuria, 24 Hour Urinary Albumin.



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