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IJAVMS. 2009; 3(1): 43-50

Comparative Therapeutic Efficacy of Permethrin, Benzyl benzoate and Sulfur in the treatment of Scabies Patients

Muhammad Mushtaq, Muhammad.A.Khan, Muhammad Younus, Muhammad K. Shahzad,Muhammad Tariq, Roubina Kausar.

This study was designed to evaluate the comparative therapeutic efficacy and side effects of permethrin cream/lotion (5%), benzyl benzoate lotion (25%), and sulfur (10%), after one, three, and three days application at bed time in the treatment of patients of scabies. Sample size n=120 were randomly divided into 3 groups designated as A,B and C comprising of 40 individuals in each group patients in groups A,B and C were treated with permethrin, benzyl benzoate, and sulfur after one, three and three days treatment applications respectively. Severity of Lesions significantly decreased with permethrin after once a week treatment as compared to benzyl benzoate and sulfur, while pruritus was significantly reduced with permethrin as compared to benzyl benzoate and sulfur treatment after one, three and three treatment applications once a week respectively. Permethrin 5% proved to be very reliable but expensive and exhibited very few side effects when applied once at bed time. Benzyl benzoate lotion (25%) is cheap and effective but requires application on more than 1 day (3 days applications). The numbers of irritations and post scabious eczematous reactions were increased after benzyl benzoate treatment. Sulfur (10%) is the oldest anti scabietic in use and common in various preparations appears to be effective, is very cheap, safe but stains clothing and requires application on 3 successive days. On the basis of above mention parameters permethrin (5%, once for 8-14 hours) finds to be effective, well tolerated and safe but expensive, proved to be the drug of choice followed by benzyl benzoate and sulfur in scabietic patients.

Key words: Efficacy, Scabies, Scabies Drug Therapy

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