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IJHSR. 2016; 6(4): 487-496


Gene Therapy in the Management of Head and Neck Cancers: A Review.

Altaf Hussain Chalkoo, Saima Tariq, Zahoor Ahmad Bhat.

Abstract
Cancer a general name for a group of more than 100 diseases is characterised by excessive and uncoordinated growth that persists in the same excessive manner after cessation of the stimuli which evoked the change. With a remarkable worldwide incidence oral squamous cell carcinoma commonly referred as oral cancer is one among the group that has a fairly poor prognosis. Despite advances in surgery, radiotherapy, and chemotherapy, the survival of patients with oral squamous cell carcinoma has not significantly improved over the past several decades. A novel approach to treatment that is currently being investigated is GENE THERAPY. Gene therapy essentially consists of introducing specific genetic material into target cells without producing toxic effects on surrounding tissue. Different treatment approaches are revealed for cancer gene therapy; gene addition therapy, suicide gene therapy, immunotherapy. In this paper different types of gene therapies are discussed along with an insight into future of this treatment modality.

Key words: oral cancer, gene therapy, suicide gene therapy, immunotherapy.



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