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Egypt. J. Exp. Biol. (Zoo.). 2016; 12(1): 23-30


PROTECTIVE ROLE AND AMELIORATING EFFECT OF VITAMIN E IN HEPATIC AND RENAL FUNCTIONS OF MICE TREATED WITH ALUMINUM CHLORIDE

Ahmed A. Massoud, Mona M. Hegazi, Ahmed A. Hashem, Noha S. Basuony.

Abstract
A total number of 250 adult male albino mice were randomly divided into 3 groups: control group and three treated groups exposed to three levels of AlCl3 (25, 50, and 100 mg/kg). Each one of the treated groups divided into three subgroups; the first subgroup treated with AlCl3 only for 2, 4, and 8 weeks, the second subgroup treated with AlCl3 plus vitamin. E (3 mg/kg) for the same periods of time. Biochemical findings in this study showed highly significant increase in activity of serum: aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphates (ALP), bilirubin concentration, urea and creatinine levels in AlCl3 treated mice. Also was showed significant decrease in total protein and albumin concentration all over the experimental period compared to control group. While mice treated with AlCl3 plus vitamin E showed significant reduction in activity of AST, ALT, ALP, bilirubin concentration, serum urea, and creatinine levels and showed significant increase in total protein and albumin concentration compared to control and mice treated with AlCl3. Scanning electron microscopy and X-ray microanalysis showed that normal values of aluminum concentration in the liver tissue in the control mice were 0.6%. These values were increased to 4.0% after treatment with 100 mg/kg of AlCl3 for 4 weeks, but in mice treated with AlCl3 and with vitamin E together for the same period the values were decreased to 1.2%. The normal values of aluminum concentration in the kidney tissue in the control mice were found to be 0.2% in the cortex and 0.3% in the medulla. These values were increased to 2.8% in the cortex and to 3.7% in the medulla after treatment with 100 mg/kg of AlCl3 for 4weeks, but in mice treated with AlCl3 and vitamin E simultaneously the values were decreased to 0.7% in the cortex and to 1% in the medulla.

Key words: Aluminum toxicity, liver function, kidney function, SEM microanalysis, vitamin E.



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