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Original Article

Natl J Community Med. 2014; 5(1): 29-32

Can HbA1c Act as a Surrogate Marker for Cardiovascular Risk?

Manish B Patel; Wasimahmed M Sachora; Ashay R Pandya; Abhimanyu D Kothari; Jigar K Patel.

"Aim: Glycosylated hemoglobin is a used marker for long-term glyce-mic control. This investigation is an attempt to evaluate the diagnos-tic value of HbA(1c) in predicting cardiovascular risk
Materials and methods:The study was conducted in V.S general hos-pital. 278 subjectsduringMay 2012 to October 2012, were included in the study. Details regarding to age, gender, duration of diabetes, were taken. Venous blood samples were collected and analyzed for glyco-sylated hemoglobin (HbA1c), fast-ing plasma glucose (FPG), Total Cholesterol, Triglycerides, HDL-C and LDL-C and AIP
Results:The total cholesterol and LDL cholesterol were significantly higher in females as compared to male diabetics. TG levels and AIP ratio were raised in the subjects 55 years. In cases with duration of di-abetes > 6 years HbA1c, total cho-lesterol, TG,LDL cholesterol and AIP ratio were elevated but only total cholesterol and LDL choles-terol werestatistically significant. All the lipid parameters except HDL cholesterol were higher in subjects with HbA1c >7 % as com-pared to the group with HbA1c < 7%.
Conclusion: The findings indicate that HbA1c can provideauxiliary information about theextent of cir-culating lipids and AIP, and can thus be used as a predictor of car-diovascular risk in diabetics

Key words: Diabetes;Dyslipidemia;HbA1c;AIP

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