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Seroprevalence of antistreptolysin O antibodies in a tertiary health care centre in Haryana, India: a three year retrospective study

Aakanksha Sharma, Shipra Agarwal, Kiran Bala, Uma Chaudhary.

Background: Presence of antistreptolysin O antibodies in a patientís sera may be an isolated evidence of recent infection by group A or less commonly, group C or G Streptococcus, especially in patients suspected of having a non suppurative sequel to this infection.
Methods: A retrospective study was done on the sera samples received in the Department of Microbiology, PGIMS Rohtak, India for the detection of ASO, over a period of three years. The test was carried out by latex agglutination rapid test kit by Aspen.
Results: A total of 4632 samples were received in the laboratory during the study period. Of these, 1058 (22.8%) were found to be positive for the presence of ASO having titre of >200 IU/mL.
Conclusions: The prevalence of ASO was found to be highest in the age group 0-20. The presence of elevated streptococcal antibody titres in such a population reflects a high background prevalence of streptococcal infections. Thus, determination of ASO antibodies should be taken into consideration when evaluating the role of group A streptococcus in non-purulent complications of infections.

Key words: Antistreptolyin O antibodies, Seroprevalence, ASO titer

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