Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article

PAFMJ. 2015; 63(3): 348-352


COMPARISON OF LEVOBUNOLOL AND BRIMONIDINE IN PROPHYLAXIS OF INTRAOCULAR PRESSURE (IOP) RISE FOLLOWING ND:YAG LASER CAPSULOTOMY

Munawar Habib, Amjad Akram, Omer Farooq.

Abstract
Objective: To compare the efficacy of topical 0.5% Levobunolol and 0.2% Brimonidine in preventing intraocular pressure rise after Nd: YAG laser posterior capsulotomy.
Study Design: Randomized controlled trial (RCT).
Setting and Duration of Study: Ophthalmology Department Combined Military Hospital Multan, from September 2010 to March 2011.
Patients and Methods: A total of 82 patients fulfilling the inclusion criteria were selected from out-patient department and randomly divided into two equal groups. Topical 0.5% levobunolol was instilled in group A while 0.2% brimonidine was instilled in group B one hour before and immediately after doing Nd:YAG laser capsulotomy. The intraocular pressure (IOP) was measured using Goldmann applanation tonometer 1, 3 and 24 hours later. Data was analyzed using SPSS version 15.0.
Results: There was no statistically significant difference in mean IOP between 0.5% Levobunolol group (Group A) and 0.2% Brimonidine group (Group B) at 1 hour, 3 hours and 24 hours after Nd:YAG laser capsulotomy. The mean intraocular pressure (IOP) one hour after Nd:YAG laser and topical treatment in group A was 16.101.60 mmHg while in group B was 15.65 3.01 mmHg (P=0.401). Mean IOP after three hours in group A was 15.80 1.35 mm Hg and in group B was 15.05 2.15 mmHg (p=0.062). Mean IOP after 24 hours in group A was 15.13 2.05 mmHg while in group B was 14.32 1.62 mmHg (p=0.058).
Conclusion: Both 0.5% Levobunolol and 0.2% Brimonidine are equally effective in controlling the IOP spike after Nd: YAG laser capsulotomy. Either of these medicines can be used as a prophylaxis to prevent rise in IOP after Nd:YAG laser capsulotomy.

Key words: Brimonidine, Levobunolol, Nd:YAG laser posterior capsulotomy, Posterior capsular opacification.



Share this Article


Advertisement
American Journal of Physiology, Biochemistry and Pharmacology

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Author Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons