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Correlation of liver enzymes with serum ferritin levels in β-thalassemia major

Rameshwar L. Suman, Anuradha Sanadhya, Pradeep Meena, Suresh Goyal.

Abstract
Background: Liver is the earliest site of iron deposition in transfusion dependent β -thalassemia major and iron induced liver injury is the common cause of morbidity. Liver enzymes are raised and indicative of liver injury in transfusion dependant β-thalassemia major patients. Objective of the study was to find out the correlation of serum ferritin with liver enzymes serum glutamic oxalocetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) in thalassemia major children.
Methods: Hospital based study of fifty five (55) children of β-Thalassemia major in the age group of 4-20 years who were regularly transfused and were on oral iron chelators since at least one year were enrolled. Serum ferritin levels and serum SGOT and SGPT levels were estimated and results were correlated.
Results: Out of total fifty five (55) children, most were in the age group of 4 to 8 years. Mean rate of blood transfusion in subjects was 157.01ml/kg/year and mean duration of chelation therapy was 2.34 years. Serum ferritin levels were increased in β-thalassemic children with average of 2130.33859.85ng/ml. The SGOT and SGPT were also raised significantly (p value

Key words: Hemolytic anemia, Liver enzymes, Serum ferritin, β-Thalassemia



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