Effect of intraoperative esmolol infusion on postoperative stress response in a group of laparoscopic cholecystectomy patientsNecla Dereli, Zehra Baykal, Münire Babayiğit, Handan Güleç, Hakan Buluş, Eyüp Horasanlı.
Purpose: We aimed to analyze effects of esmolol on intraoperative anesthetic-postoperative analgesic requirements, postroperative cortisol and prolactin levels.
Material and Methods: Sixty patients have been included. Study groups were as follows; 1: Esmolol infusion was added to propofol and remifentanil, 2: Only propofol and remifentanil, 3: Esmolol infusion was added to desflurane and remifentanil, 4: Only desflurane and remifentanil was used. Preoperative and postoperative cortisol and prolactin levels were measured.
Results: Analgesic requirements were significantly lower in group 1 and was lower in group 3 compared to group 4. Heart rates were significantly lower in esmolol groups (group 1 and 3) compared to their controls. Prolactin levels significantly increased postoperatively in all groups compared to preoperative levels. We observed a significant decrease in cortisol levels postoperatively in group 1 compared to preoperative levels.
Conclusion: Using adjuvant esmolol during anesthetic maintenance of laparoscopic cholecystectomy patients decreases anesthetic analgesic requirements without causing any hemodynamic instability, and supresses postoperative cortisol response but does not have any significant effect on postoperative prolactin response.
Esmolol, postoperative stress response, cortisol, prolactin
American Journal of Physiology, Biochemistry and Pharmacology
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