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Cukurova Med J. 2017; 42(1): 77-85

Effect of intraoperative esmolol infusion on postoperative stress response in a group of laparoscopic cholecystectomy patients

Necla Dereli, Zehra Baykal, Münire Babayiğit, Handan Güleç, Hakan Buluş, Eyüp Horasanlı.

Purpose: We aimed to analyze effects of esmolol on intraoperative anesthetic-postoperative analgesic requirements, postroperative cortisol and prolactin levels.
Material and Methods: Sixty patients have been included. Study groups were as follows; 1: Esmolol infusion was added to propofol and remifentanil, 2: Only propofol and remifentanil, 3: Esmolol infusion was added to desflurane and remifentanil, 4: Only desflurane and remifentanil was used. Preoperative and postoperative cortisol and prolactin levels were measured.
Results: Analgesic requirements were significantly lower in group 1 and was lower in group 3 compared to group 4. Heart rates were significantly lower in esmolol groups (group 1 and 3) compared to their controls. Prolactin levels significantly increased postoperatively in all groups compared to preoperative levels. We observed a significant decrease in cortisol levels postoperatively in group 1 compared to preoperative levels.
Conclusion: Using adjuvant esmolol during anesthetic maintenance of laparoscopic cholecystectomy patients decreases anesthetic – analgesic requirements without causing any hemodynamic instability, and supresses postoperative cortisol response but does not have any significant effect on postoperative prolactin response.

Key words: Esmolol, postoperative stress response, cortisol, prolactin

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American Journal of Physiology, Biochemistry and Pharmacology


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