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Cukurova Med J. 2013; 38(1): 103-107

Synthesis and Antifungal Activity of New Heterocyclic Compounds

Zafer Asım Kaplancıklı, Mehlika Dilek Altıntop, Gülhan Turan-Zitouni, Ahmet Özdemir, Rasime Demirel, Usama Abu Mohsen, Weiam Hussein.

Purpose:The objective of this study was to describe the synthesis of 2-arylthio-N-(2-methoxydibenzo[b,d]furan-3-yl)acetamide derivatives as heterocyclic compounds and focused on their potential antifungal effects against fungi species.
Method: The reaction of 2-chloro-N-(2-methoxydibenzo[b,d]furan-3-yl)acetamide with various aromatic thiols gave 2-arylthio-N-(2-methoxydibenzo[b,d]furan-3-yl)acetamide derivatives. Antifungal activities of the synthesized compounds have been evaluated using microbroth dilution method.
Results: Four new heterocyclic compounds were synthesized. All compounds were as effective as ketoconazole against T. harzianum, A. ochraceus, C. albicans, whilst the compounds were more effective than ketoconazole against F. solani, F. moniliforme, F. culmorum.
Conclusion: All synthesized compounds showed significant antifungal activity when compared with ketoconazole.

Key words: Antifungal activity, Microbroth dilution method, Dibenzofuran, Heterocyclic compound

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