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23

PAFMJ. 2016; 66(3): 386-389


NEPHROTOXICITY BY ORAL VANADYL SULPHATE IN RATS

Syed Zubair Hussain Shah, Abdul Khaliq Naveed, Amir Rashid.

Abstract
Objective: To estimate urea and creatinine as markers of nephrotoxicity after six months of administration of vanadyl sulphate (VOSO4) to rats.
Study Design: A randomized controlled trial.
Place and Duration of Study: A was conducted at Department of Biochemistry and Molecular Biology, Army Medical College, National University of Sciences and Technology, Rawalpindi for duration of one year.
Material and Methods: A total of 105 Sprague Dawley rats were randomly divided into three groups of 35 rats each. Group I was control while animals of groups II and III were administered 0.25mg/Kg/day and 1.2mg/Kg/day vanadyl sulphate respectively for duration of 24 weeks. At the end of the experiment, serum urea and creatinine were estimated. Means with standard deviation of both parameters were calculated and statistical significance of differences among the groups was determined by one way ANOVA followed by post hoc Tukey’s test.
Results: Urea and creatinine were found to be significantly raised in treated groups as compared to the control group in a dose dependent manner.
Conclusion: Oral vanadyl sulphate causes nephrotoxic effects in usual doses for prolonged duration in healthy laboratory rats and thus its use in humans must be reconsidered.

Key words: Nephrotoxicity, Sprague Dawley rats, Vanadyl sulphate.



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