Background:- Modification of the root surface by various means, known as biomodification procedures, has been introduced by using a
variety of physical and chemical agents, in order to detoxify, decontaminate, and demineralise the root surface. Citric acid is the oldest and
most frequently used root biomodifying agent as it removes the smear layer, accelerates new attachment. Materials and methods:- EBSCO
HOST was searched for entries since 1966 – 2014, which included:- Journal of Periodontology, Annals of Periodontology, Periodontology
2000, Journal of Clinical Periodontology, International Journal of Periodontics and Restorative dentistry, Journal of Indian Society of
Periodontology and Journal of Periodontal Research. Results:- Out of 20 studies, only 6 reported evidence of regeneration, for citric acid.
Conclusion:- The role of citric acid as a root biomodifying agents in regeneration is still unpredictable and questionable.
Root biomodification, regeneration, growth factors