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IJCRR. 2016; 8(13): 31-34


STUDY OF OXIDATIVE STRESS PARAMETERS IN TYPE-II DIABETES MELLITUS AND THEIR CORRELATION WITH BLOOD GLUCOSE LEVEL

Prakash P. Malam, Anand J. Amin, Ashish C. Zala, Vipul M. Navadiya, Dhruv Patel, Dharna A. Patel.

Abstract
Objective: Increasing evidence has underlined the importance of oxidative stress in the pathophysiology of type-II diabetes mellitus and its contribution to the associated complications. However the correlation between oxidative stress parameters and blood glucose levels is not clearly understood.
Method: Present study was done to evaluate the oxidative stress parameters in patients with type-II diabetes mellitus and to check the correlation, if any, between these parameters and blood glucose. Plasma malondialdehyde and superoxide dismutase levels were measured in thirty type-II diabetes mellitus and thirty normotensive subjects. Fasting and post-prandial blood glucose correlation was analyzed by Pearsonís correlation.
Result: Enhanced oxidative stress was observed in type-II diabetes mellitus subjects as denoted by raised plasma malondialdehyde levels and reduced superoxide dismutase levels.
Conclusion: Plasma malondialdehyde correlated positively whereas superoxide dismutase showed negative correlation with blood glucose in type-II diabetes mellitus subjects. No significant correlation was observed between these parameters and blood glucose levels in normotensive controls.

Key words: Oxidative stress, Type-II diabetes mellitus, Correlation, Malondialdehyde, Superoxide dismutase



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