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IJCRR. 2016; 8(13): 42-49


SYNTHESIS AND APPLICATIONS OF SUGAR FLUORINATED NUCLEOSIDES

Mohamed Ibrahim Elzagheid.

Abstract
In this review, different methods that have been used for the synthesis of 1-, 2-, 3-, 4- and 5-sugar fluorinated nucleosides and their analogous are presented and different fluorinating agents are listed. Highlighted examples of the sugar fluorinated nucleosides that make a great impact on chemistry, biochemistry, and drug discovery are also elaborated. This review has shown that introduction of a fluorine atom in different positions within the sugar structure of the nucleoside improves their reactivity and properties.

Key words: Nucleosides synthesis and applications, Sugar fluorinated nucleosides, Fluorinating agents



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