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Natl J Integr Res Med. 2012; 3(3): 160-164


CSF-ADA As Diagnostic Tool For Tuberculous Meningitis Patients

Dr Margeyi Mehta*, Dr Jigish Shah**, Dr A T Leuva***.

Abstract
Introduction : TB is widely prevalent in India and a common form of TB is Tuberculous Meningitis (TBM), with great mortality, mainly in childhood. Available methods of TBM diagnosis are time-consuming and expensive. ADA is being recognized as marker of T-cell-mediated immunity. There is a need for cost-effective and relatively rapid method at tertiary-healthcare-settings. The study was carried out to assess the role of CSF-ADA for TBM diagnosis. Materials and Methods : In this cross-sectional study at SSG Hospital, Baroda between June-October 2011, 50 patients and 20 controls were selected. ADA in CSF and other biochemical markers were assessed after due informed consent. Microxpress ADA-MTB reagent was used for CSF-ADA estimation.
Results : Out of 50, 22 children were male and 28 were female. 17 TBM (34%), 19 PM (38%) and 14 AM (28%) cases were detected. 72% of cases had CSF-ADA levels less than 10 IIU/L (mean 4.371.32), CSF-ADA levels were less than 10 in all controls (mean 2.80.8). Comparative CSF-ADA estimation in TBM, PM and AM showed higher values for TBM (p

Key words: Adenosine Deaminase, Tuberculous meningitis diagnosis, CSF-ADA



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