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IJHSR. 2016; 6(8): 98-104


Detection of Tissue Factor Pathway Inhibitor-2 (TFPI-2) Gene Mutation in Sudanese Pediatric Patients with Leukemia.

Eihab Idris Mohammed, Babikr Ahmed Mohamed, Fath Elrahman Mahdi Hassan Gameel, Mansoor Mohammed Mansoor.

Abstract
Aim: we conducted our study to detect (TFPI-2) Gene Mutation in Sudanese Pediatric Patients with leukemia.
Materials & Methods: This study is a prospective analytical case control study was conducted to detect (TFPI-2) gene mutation in 98 Sudanese pediatric patients with leukemia; the population comprises all male and female pediatric patients, during the period of collection (2014-2015) admitted in Khartoum Radiation and Isotopes Centre (RIC), 97 individual pediatric (0 - 15 years) male and female apparently healthy from primary, Kindergartens and nurseries schools are selected as control group.
Results: Males comprised 52 (53.1%) while females are 46 (46.9%). The case group in our study was divided into three subgroups based on type of leukemia ALL, AML and CML. The frequency of ALL was 81 (82.7%), AML 12 (12.2%) and CML 5 (5.1%). TFPI-II gene detected in all samples, there were 14 (14.3%) in the patients group have mutation, 10 (71.4%) out of them were Homozygous and 4 (28.6 %) were Heterozygous. There is insignificant correlation between the patients which TFPI-II gene mutation have and other patients (p=0.635).
Conclusion: We concluded that ALL is the most common among Sudanese children and no strong association with TFPI-2 gene polymorphism and Sudanese pediatric patients with leukemia (p=0.635). Only 14.3% of Sudanese pediatric patients with leukemia have TFPI-II gene mutation.

Key words: TFPI-2, mutation, pediatric, leukemia.



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