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Study of lipid and non-lipid effects of statins in hypertensive patients

Shashikala E., Raghawa Rao B. N. V..

Background: Hypertension is one of the commonest diseases affecting the mankind which is associated with endothelial dysfunction and left ventricular dysfunction and hence the study is aimed to observe the effects of statins on endothelial and left ventricular dysfunction.
Methods: 15 hypertensive patients were given atorvastatin for 4 weeks and compared with sex and aged matched 15 controls after a detailed Clinical history, clinical examination, biochemical investigations, chest X-ray, electrocardiogram, echocardiogram and Doppler study of brachial artery.
Results: Both study group and control group consisted of 10 males and 5 females who have dyslipidemia, endothelial and ventricular dysfunction. After a 4 weeks of study, in study group, flow mediated brachial artery diameter (FMD%) increased significantly (11.39%, P

Key words: Atorvostatin, Endothelial dysfunction, Hypertension, Lipid and non-lipid effects, LV dysfunction

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