Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access


Rate pressure product predicts cardiovascular risk in type 2 diabetics with cardiac autonomic neuropathy

Rishu Segan, Vidushi Gupta, Lily Walia, Naveen Mittal.

Cited by (4)

Background: Unexplained sudden deaths due cardiac involvement are linked to autonomic neuropathy in diabetics but mechanisms remain unclear. Heart rate and pulse pressure etc have been used to predict cardiovascular risk. But the association of Rate Pressure Product remains unascertained.

Objective: To predict cardiovascular risk in type 2 diabetic patients with cardiac autonomic neuropathy using a non-invasive indicator, rate pressure product.

Materials and Methods: Case control study done on two groups of 20 each, age matched type 2 diabetics with/without cardiac autonomic neuropathy and matched with 20 controls of either sex (n=60). Rate Pressure Product was measured in response to cold pressor and hand grip test. Statistical analysis was done using SPSS software by paired and unpaired t test.

Results: There was a significant increase in rate pressure product in controls and in patients without autonomic neuropathy after the tests (p0.001). The change in RPP (ΔRPP) was least in diabetics with autonomic neuropathy and significant in controls and non-neuropathy diabetics using unpaired t-test ( p< 0.05 ). Resting RPP was recorded highest in diabetic autonomic neuropathy patients.
Conclusion: Heightened resting RPP and failure of Rate Pressure Product increment during cardiac sympathetic stimulation promotes aggravated ischemic episodes. This renders autonomic neuropathy diabetics vulnerable to adverse cardiovascular events leading to increased morbidity and mortality.

Key words: Rate Pressure Product, Autonomic neuropathy, Diabetes Mellitus

Share this Article

Progress in Orthopedic Science


ScopeMed Home
Follow ScopeMed on Twitter
Article Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons