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Natl J Med Res. 2012; 2(3): 362-365


Sero-Prevalence of Hepatitis B amongst Pregnant Women Attending the Antenatal Clinic of a Tertiary Care Hospital, Jamnagar (Gujarat).

Vipul Mansukhbhai Khakhkhar, Pragnesh Jayantilal Bhuva, Shaswati Pragnesh Bhuva, Chirag P Patel, Cholera Meera S.

Abstract
Abstract:
Background: Majority of the transmission of Hepatitis-B in India and other developing countries occurs by vertical transmission from an infected carrier mother to the neonate, intrapartum or antenatally. Up to 90% of babies born to carrier mothers may also become carriers and they are at a very high risk of developing chronic liver disease at a younger age. Aims & Objectives: Present study was done to know the determination of sero-markers of hepatitis B surface antigen (HBsAg) amongst pregnant women. Further, to find prevalence of HBeAg and Anti HBe-IgM Ab amongst HBsAg positive pregnant women. Methods: A retrospective study was done based on review of records of pregnant women. Blood samples were collected from 2050 pregnant women with age ranging from 16-40 years during the January 2001 to December 2003. Screening of HBs Ag was done by RPHA method and positive HBsAg tests were confirmed by ELISA. The positive samples were then further tested for HBeAg and Anti-HBe-IgM Ab. Results: Amongst, 2050 pregnant women, 63 (3.07%) were positive by RPHA and ELISA. Significant statistical association was found between HBsAg positive carriers 63, with HBeAg positive 11 (17.46%) and Anti-HBe IgM Ab positive 18 (28.57%) samples (χ2=128.14, P0.05), history of disease (χ2=6.56, P>0.05) and trimester of pregnancy (χ2=1.66, P>0.05) with HBsAg positivity in pregnant women. Though, highest HBsAg positivity was found with age group of 21-25 year (4.20%), history of Jaundice (13.95%) and third trimester of pregnancy (3.56%). Conclusion: Screening of pregnant women for HBsAg is presently practiced in order to identify those neonates at risk of transmission. However, HBsAg positive mothers should further be screened for HBV markers particularly, the test for HBeAg and Anti-HBe-IgM-Ab which suggests high chances of carrier state.

Key words: Hepatitis B, Pregnant women, Jaundice, HBs Ag, RPHA, HBe Ag, anti-HBe-IgM Ab.



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