Biochemical evaluation of different fractions of leaf and stem bark methanol extracts of Diospyros mespiliformis and the inhibitory effects of the extracts on cysteine protease of the parasite were investigated. Aspartate aminotransferase and Alanine aminotransferase studies of the leaf methanol extract showed that, there was significant (P < 0.05) increase in the n-butanol and aqueous fractions. Also, significant (P < 0.05) increase in the serum level of Alkaline phosphatase of the infected group in all the fractions. AST ALT and ALP studies of the stem bark extract had significant (P
Antimalarial, Plasmodium berghei, Biochemical parameters, Inhibition studies, Cysteine protease.