Background: Infection with Salmonella enteric a serotype Typhi (the causative agent of typhoid fever) causes an estimated 20 million cases of typhoid fever and 200,000 deaths annually worldwide.  In the United States, typhoid fever is now a rare disease, with about 400 laboratory-confirmed cases reported per year.  Not all cases are diagnosed; however, the total annual number of Salmonella serotypes Typhi infections is estimated at 5,750 cases per year, 1,900 of them acquired in the United States. 
Objective: The study was aimed at determining the prevalence and knowledge of population about typhoid fever.
Materials and Methods: In this study, 384 households were included. Questionnaire and observation was used as tools for data collection. The households was selected through a multistage cluster-sampling technique to determine the prevalence of typhoid disease, 384 respondents was selected through systemic random sampling.
Results: The overall prevalence of typhoid disease was 46.4% amongst the population surveyed. The study showed that the knowledge and awareness among the general population about typhoid disease is high 84.6%, and the study revealed that typhoid disease was more prevalent among age group (11-20 year) which represent (38.8%) of person who has typhoid disease.
Conclusions: Typhoid fever continues to be a major public health problem in Sudan. The study showed that prevalence of typhoid is high (46.4%) of study population have typhoid disease, although the knowledge of population is showed high also (84.6%).
prevalence, typhoid fever, Salmonella, knowledge, infection.