The role of HCV RNA levels and host factors in liver injury causing mild to severe fibrosis remain a debatable question. We determined the role of viral RNA load in serum and histological activity with different grades of liver injury to find any possible correlation. We studied 41 HCV infected patients who underwent liver biopsy, stage of the liver fibrosis was determined using METAVIR system and genotype and viral titer was determined. All the results were analyzed on statistical software SPSS version 16.t-test and Chi square test were applied to get significant results (p 40). This study indicates that progression of HCV liver damage can be correlated with the amount of viremia, ALP and bilirubin levels in patientâ€™s serum. High serum HCV RNA level reflected the early fibrosis stage and the viremia level decreased at the later stages.
HCV, fibrosis stages, serum HCV RNA levels, noninvasive markers