Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

23

PAFMJ. 2016; 66(5): 699-704


COMPARISON OF EFFECT OF HIGH FAT DIET INDUCED OBESITY AND SUBSEQUENT ATORVASTATIN ADMINISTRATION ON DIFFERENT ANTHROPOMETRIC MEASURES IN SPRAGUE DAWLEY RATS

Faizania Shabbir, Shakir Khan, Muhammad Javad Yousaf, Muhammad Alamgir Khan, Tausif Ahmed Rajput.

Abstract
Objective: To compare the effect of high fat diet induced obesity and atorvastatin administration on different anthropometric parameters in Sprague Dawley rats.
Study Design: Randomized control trial (RCT).
Place and duration of study: The study was conducted at Department of Physiology, Army Medical College Rawalpindi in collaboration with National Institute of Health (NIH) Islamabad and was completed in 12 months.
Material and Methods: Ninety healthy Sprague Dawley rats were taken and divided into three equal groups with 30 rats in each group. Group I rats (normal control) were given normal diet for 3 weeks. Group II rats (obese control) were given high fat diet for 3 weeks. Group III rats (obese treated) were orally given 10mg/kg/day of atorvastatin through gavage method for 3 weeks after obesity induction. At the start of the study, initial body weight and naso-anal length of all the rats in each group were recorded and then weight change was regularly recorded thrice weekly. Naso-anal length was again recorded at the end of the experiment.
Results: There was a significant increase in body weight in high fat diet induced obese and obese atorvastatin treated rats (p

Key words: Keywords: Atorvastatin, BMI, LEE Index, Obesity, Rats.



Share this Article


Advertisement
Journal of Complementary Medicine Research

SUBMIT YOUR ARTICLE NOW


ScopeMed Home
Follow ScopeMed on Twitter
BiblioCAM
Article Tools
eJPort Journal Hosting
About ScopeMed
License Information
Terms & Conditions
Privacy Policy
Suggest a Journal
Publisher Login
Contact Us

The articles in Scopemed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.
Scopemed Buttons