Aim: The study was carried out to estimate thyroid profile and serum albumin level in preeclamptic women as compare to normotensive women. In addition to this correlation between thyroid profile and albumin in preeclamptic women was also calculated.
Material and Methods: The study comprised of 60 cases of preeclamptic women who attended in Obstetrics & Gynaecology Department in Govt. Medical College, Nagpur from February 2013 to August 2014 and 60 normotensive healthy womens as controls. Serum total Tri-iodothyronine (T3), Tetraiodothyronine (T4), Thyroid Stimulating Hormone (TSH) and serum albumin were estimated.
Results: We observed that out of 60 preeclampsia patients 13 (21.66%) women having hypothyroidism, 18 (30%) women having sub-hypothyroidism and 29 (48.33%) women were of euthyroid. The mean serum TSH in preeclamptic cases (preeclampsia women) were increased significantly (p >0.001). On the other hand serumT3 levels and Serum T4 levels were decreased significantly in preeclamptic women when compared to controls (p >0.001). Serum albumin was decreased significantly in preeclamptic women when as compared to controls (p >0.001). We found that there was statistically significant positive correlation between serum T3 & T4 and serum albumin (r = 0.8735, p = 0.0001) and statistically significant negative correlation between serum TSH and serum albumin (r = - 0.6109 p = 0.0001).
Conclusion: From the results all these parameters play an important role in preeclampsia hence early detection of these parameters in preeclampsia may help to improve maternal and fetal outcome.
T3 -Total triiodothyronine, T4- Tetraiodothyronine, TSH- Thyroid stimulating hormone