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Original Article

J App Pharm Sci. 2019; 9(5): 107-111


Teratogenic effects of aqueous extract of Ficus glomerata leaf during embryonic development in zebrafish (Danio rerio)

Abusufyan Shaikh, Kalidas Kohale, Mohammed Ibrahim, Mohib Khan.

Abstract
Over past few decades, many reports published in scientific journals describing medicinal properties of Ficus glomerata. However, its effects on embryonic development and its safety characteristics have not been studied. The purpose of this investigation was to determine LC50 value and study the effect of aqueous extract of Ficus glomerata leaf on developmental abnormalities in zebrafish embryos. LC50 value of aqueous extract of Ficus glomerata leaf was calculated by using probit analysis. Effect on percentage hatchability, heartbeat rate, total body length and developmental morphological abnormalities i.e delayed growth, abnormal movement, tail detachment, abnormal head trunk angle, scoliosis/ flexure, yolk sac edema were recorded. Aqueous extract of Ficus glomerata leaf revealed LC50 of 239.88 ppm. The result showed a significant reduction in percent hatchability (p

Key words: Ficus glomerata, toxicity test, teratogenesis, embryogenesis, zebrafish



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