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Buprenorfin in opioid addiction treatment: Studies with methadone comparison

E. Cüneyt Evren, Defne Tamar, Bilge Babayağmur, Duran Çakmak.

Abstract
Methadone maintenance treatment is the most widely used
pharmacological treatment approach for opioid addiction in
many countries. In spite of many benefits that was gained after
the usage of full agonist methadone, especially high numbers
of patients who reject to join methadone treatment or who didn?
have positive outcomes despite adequate dosing caused an
urge to develop an alternative pharmacological treatment.
Buprenorphine is a partial agonist at the m-opioid receptor that
has been proposed as an alternative to traditional full agonist
maintenance therapy for the treatment of opioid addiction. In
this article the studies that compared buprenorphine with
methadone in the treatment of opioid addiction is reviewed.

Key words: buprenorphine, methadone, opioid addiction



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