Objective: Effects of chlorpromazine and haloperidol on erythrocyte
glucose 6-phosphate dehydrogenase enzyme activity
were investigated in invitro conditions.
Methods: Glucose 6-
phosphate dehydrogenase was purified from human erythrocyte.
Enzyme activity was determined according to the Beutler
method by using a spectrophotometer at 340 nm.
results of study showed that I50 values were 0,42 mM for chlorpromazine
and 0,37 mM for haloperidol in invitro study.
Conclusion: The results of this study suggested that chlorpromazine
and haloperidol have significant inhibition effect on the
activity of glucose 6-phosphate dehydrogenase enzyme in invitro.
chlorpromazine, haloperidol, glucose 6-phosphate dehydrogenase, erythrocyte, in vitro