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In vitro effects of chlorpromazine and haloperidol on human erythrocyte glucose-6-phosphate dehydrogenase enzyme

Mehmet Emin Büyükokuroğlu, Sayit Altıkat, Mehmet Çiftçi, Zekiye Nur Banoğlu, Fatma Göçer.

Objective: Effects of chlorpromazine and haloperidol on erythrocyte
glucose 6-phosphate dehydrogenase enzyme activity
were investigated in invitro conditions.

Methods: Glucose 6-
phosphate dehydrogenase was purified from human erythrocyte.
Enzyme activity was determined according to the Beutler
method by using a spectrophotometer at 340 nm.

Results: The
results of study showed that I50 values were 0,42 mM for chlorpromazine
and 0,37 mM for haloperidol in invitro study.

Conclusion: The results of this study suggested that chlorpromazine
and haloperidol have significant inhibition effect on the
activity of glucose 6-phosphate dehydrogenase enzyme in invitro.

Key words: chlorpromazine, haloperidol, glucose 6-phosphate dehydrogenase, erythrocyte, in vitro

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American Journal of Physiology, Biochemistry and Pharmacology


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