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The efficacy of fluoxetine treatment in children and adolescents with posttraumatic stress disorder symptoms

Özgür Yorbık, Semih Dikkatli, Adnan Cansever, Teoman Söhmen.

Abstract
Objective: The aim of this study is to investigate the effectiveness
of fluoxetine on the symptoms of posttraumatic stress disorder
(PTSD) with children and adolescents.

Method: This study was
performed with 26 children and adolescents (10 males, 16
females), aged between 7 and 17 (mean: 13.0?2.8Ğyear), because
of PTSD symptoms developed after earthquake disaster
happened in Turkey. PTSD diagnosis was made according to
DSM-IV. The Clinical Global Impression Scale, and the
Posttraumatic Stress Disorder Symptoms Check List which was
developed in our department were used to assess the
effectiveness of 7-20mg (mean: 15.1?5.3 mgĞday) fluoxetine
treatment which lasted between 30 and 76 days (mean:
55?10.91days).

Results: According to the Clinical Global
Impression Scale, 9 subjects (34.6%) improved very much, 14
subjects (53.8%) improved much, 1 subjects (3.8%) improved
slightly, 1 subjects (3.8%) did not change, and 1 subjects (3.8%)
worsened. Fluoxetine caused statistically significant improvements
on all PTSD symptoms according to the Posttraumatic Stress
Disorder Symptoms Check List.

Conclusion: In this study, it was
observed that fluoxetine was effective on symptoms of
reexperiencing, of avoidance of stimuli associated with trauma,
of numbing of general responsiveness, and of increased arousal
which happened after earthquake trauma to the children and
adolescents.

Key words: posttraumatic stress disorder, fluoxetine, drug therapy, child, adolescent, earthquake, natural disaster



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