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Pharmacogenomics in the treatment of psychiatric disorders

Ercan Abay, İbrahim Ateş.

Abstract
Pharmacogenomics is a young field which uses genetic information
to predict drug treatment response. Genes that are
involved in the pathogenesis of psychiatric disorders and that
influence drug treatment response have been the focus of
investigation recently and candidate genes and their variants
have been identified. The rapidly developing molecular
genetic techniques contributed the advance in this field. At
present, psychiatric treatment is based on a trial-and-error
paradigm and therefore practiced empirically.
Pharmacogenomic knowledge of psychiatric treatments will
improve outcome by determining most beneficial drug
according to the individual's genetic information. Data to
date on psychopharmacogenomics is reviewed in this article.

Key words: Pharmacogenomics, psychotropic drugs, pharmacogenomic knowledge, psychopharmacogenetics, schizophrenia



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