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The relationship between high sensitive C-Reactive protein levels and treatment response in patients with major depression

Medaim Yanık, Özcan Erel, Abdurrahman Altındağ, Mahmut Katı.

Abstract
Objective: Many previous studies conducted about the levels of
C-reactive protein (CRP) in patients with ajor depression presented
contradictory results which ight be a result of limitations in
measurement of serum levels of CRP. However,even minor
alterations of CRP levels can be determined with using recently
developed high sensitive CRP (hs-CRP) measurement method. Till
now, there have not been any studies investigating for CRP levels in
major depressive patients using hs-CRP method. The aim of this study
was to determine serum hs-CRP levels in patients with major
depression who were treated with various antidepressants and to
compare with those of healthy controls.

Methods: Twenty-three patients who are diagnosed clinically as
major depression and 26 healthy controls were included in this study.
The severity of the depression was quantified with 17-item Hamilton
Depression Rating Scale (HAM-D). Serum hs-CRP levels were
measured before and after antidepressant treatment of eight weeks.

Results: Serum hs-CRP levels were found as 0.75 ± 0.34 mg/dl and
0.76 ± 0.48 mg/dl before and after treatment respectively in major
depression group. The difference was not statistically significant
according to paired samples T test (p>0.05). The level of healthy
group was 0.71 ± 0.49 mg/dl and the difference between control
group and major depression group was also insignificant (p>0.05).

Discussion: The results of this study showed that serum CRP levels in
major depressive patients as measured with hs-CRP measurement
method ? a 30 fold ore sensitive method for CRP serum levels than the
methods used in previous studies-do not show any significant
differences from healthy control group and do not change in quantity
with various antidepressant treatments.

Key words: high sensitive C reactive protein, hs-CRP, C-reactive protein, acute phase response, depression



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