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Olanzapine treatment in choreoathetosis due to bilateral striopallidodentate calcinosis

Hatice Balaban, Turker Sahiner, Eylem Degirmenci.

Bilateral Idiopathic Striopallidodentate Calcinosis (BISPDCs) refers to idiopathic calcification of the basal ganglia and secondary striato-dentate
calcinosis. Its definition comprises numerous metabolic abnormalities including disturbances of calcium and phosphorous metabolism. In this
article, a case with BISPDCs secondary to hypoparathyroidism who presented with generalized choreoathetosis has been reported. A daily dose
of 2.5 mg of olanzapine has been initiated and increased gradually up to doses 10 mg/daily. In six weeks time, the patient was almost free from
choreoathetosis. Thus, olanzapine may be a good choice at the symptomatic treatment of choreoathetosis due to BISPDCs.

Key words: striopallidodentate calcinosis, olanzapine, choreo-athetosis

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American Journal of Physiology, Biochemistry and Pharmacology


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