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Methylphenidate Increases cGMP Levels in Rat Brain

Tümer Türkbay, Ayhan Cöngöloğlu, Ali Doruk, Ahmet Aydın, Ahmet Sayal.

Objective: Methylphenidate (MPH) is commonly and effectively used to treat children and adolescents with attention-deficit hyperactivity disorder.
However, MPH still poses a number of questions on which mechanisms of effect it has on the brain. The present study addresses the question of
whether MPH induces cyclic guanosine 3',5?-monophosphate (cGMP) in rat brain.

Methods: MPH at a dose of 10mg /kg p.o. was administered to
rats daily for 8 weeks, whereas control rats were given distilled water. The level of cGMP was measured in total brains of the rats.

Results: Brain
cGMP levels were higher in the study group when compared with the control group (p=0.004).

Conclusions: Our results suggested that the long
term MPH administration might increase cGMP activity in rat brain.

Key words: methylphenidate, cGMP, secondary messenger

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Journal of Behavioral Health


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