Objective: Methylphenidate (MPH) is commonly and effectively used to treat children and adolescents with attention-deficit hyperactivity disorder.
However, MPH still poses a number of questions on which mechanisms of effect it has on the brain. The present study addresses the question of
whether MPH induces cyclic guanosine 3',5?-monophosphate (cGMP) in rat brain.
Methods: MPH at a dose of 10mg /kg p.o. was administered to
rats daily for 8 weeks, whereas control rats were given distilled water. The level of cGMP was measured in total brains of the rats.
cGMP levels were higher in the study group when compared with the control group (p=0.004).
Conclusions: Our results suggested that the long
term MPH administration might increase cGMP activity in rat brain.
methylphenidate, cGMP, secondary messenger