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Genetic findings of obsessive-compulsive disorder

Mehmet Murat Demet.

Abstract
Obsessive-compulsive disorder (OCD) is characterized by repetitive,
intrusive ideations, image or urges (obsession) and/or rigid, ritualistic
and time-consuming behaviours (compulsions). Early evidences on
inheritance of OCD have been obtained from family and twin studies.
Segregation analysis provides basic support for existence of a major
gene locus. In only published linkage analysis, it was reported that
multipoint linkage was found on chromosome 9p. Recently, genetic
studies have centered on plausible candidate genes, which are
thought to be involved in the etiology of OCD. Preliminary findings
from the studies of several candidate genes have contributed to
previous clinical findings, especially related to serotonergic and
dopaminergic systems. Also, the candidate genes of opioid,
glutamatergic systems as well as the genes of immune system and
neurodevelopmental progress give hope to researchers for future
investigation of these systems. In this review, the family, twin,
segregation, linkage, and candidate genes studies of OCD will be
reviewed.

Key words: bsessive-compulsive disorder, genetics, segregation, linkage, candidate gene



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